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KMID : 0876319990010010061
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Cachon Medical Journal
1999 Volume.1 No. 1 p.61 ~ p.69
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Diagnostic Use of in Vivo Confocal Microscopy in Infectious Keratitis
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Cho Beom-Jin
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Abstract
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Purpose: To demonstrate in vivo confocal microscopic features of infecting microorganisms in Acanthamoeba and fungal keratits patients.
Materials and Methods: A series of seven infectious keratitis presenting clinical features which suggested Acanthamoeba and fungal keratitis were examined using Tandem Scanning Confocal Microscope in vivo. The confocal microscopic diagnoses were confirmed later b culture of the microorganisms or clinical response to specific treatment to the confocal microscopic diagnoses.
Results: In Acanthamoeba keratitis, highly reflective round or ovoid organisms with the diameter of about 10-25um were visualized distinctly against relatively dark normal parenchymal structures, such as epithelial cells or keratocyte unclei. Doubled-walled structures of Acanthamoeba cyst were clearly demonstrated in some cases. In fungal keratitis, hyphae were imaged as hyperfluorescent, long, parenchymal structures of relatively weak iridescence. Along the long axis of these filaments, there are some interruptions visualized suggesting septae.
Conclusion: In vivo confocal microscopy may be a fast, easy and safe diagnostic tool for identifying the infecting microorganisms in some infectious keratitis.
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KEYWORD
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Acanthamoeba keratitis, Fungal keratitis, Infectious keratitis, In vivo confocal microscopy
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